Atypical Symptoms of B12 deficiency
Last Updated on 02/24/2026 by Farid Helal
I think you may know the common symptoms of vitamin B12 deficiency, but do you know the atypical ones? Maybe, not! As many of us have never heard about them.
In this article, we will explore these often overlooked signs. We will also delve into the atypical ones. Furthermore, we will shed light on their importance in diagnosing B12 deficiency.
What is B12 deficiency?
It is a condition when the body doesn’t have enough Vitamin B12, leading to anemia and neurological problems. Symptoms typically include fatigue, weakness, and nerve damage. It’s often due to poor absorption or diet. Treatment involves B12 supplements or injections.
However, there is a range of lesser-known, atypical symptoms, that can also indicate a vitamin B12 deficiency. Those include Psychological, neurological, and other symptoms.
Symptoms of B12 deficiency: Typical and Atypical
Psychological Signs and Symptoms
1- Cognitive Impairment and Memory Loss
One of the surprising atypical symptoms of B12 deficiency is cognitive impairment and memory loss. Inadequate levels of B12 can lead to decreased cognitive function, difficulty concentrating, and memory problems. These symptoms are often mistaken for signs of aging or stress. However, B12 deficiency should be considered as a potential underlying cause, especially in older adults.
2- Mood Disorders
B12 deficiency has been linked to mood disorders such as depression, anxiety, and irritability. The exact mechanism behind this association is still not fully understood. However, many believe that B12 plays a crucial role in producing neurotransmitters such as serotonin. It also helps in regulating dopamine and norepinephrine. Insufficient levels of B12 can disrupt the delicate balance of these neurotransmitters, leading to mood disturbances.
Neurological Signs and Symptoms
3- Dizziness and Balance Issues
An unexplained feeling of dizziness or problems with balance can be an unexpected manifestation of B12 deficiency. The deficiency affects the nervous system, including the peripheral nerves responsible for transmitting signals related to balance and coordination. Consequently, individuals deficient in B12 may experience difficulties with spatial orientation, vertigo, or even unsteady gait.
4- Muscle Weakness and Tremors
Muscle weakness and tremors are often associated with other conditions, but they can also be indicative of B12 deficiency. The deficiency affects the nerves that control muscle movement, leading to weakness, trembling, or even difficulty walking. Identifying B12 deficiency as the underlying cause is vital to prevent long-term complications.
5- Vision Changes
Although less common, vision changes can occur in individuals with B12 deficiency. Blurred or distorted vision may indicate optic nerve damage. Sensitivity to light also suggests a deficiency of this essential vitamin. Prompt recognition and treatment of B12 deficiency can prevent further deterioration of vision.
Atypical Symptoms of B12 deficiency
1- Pale or Yellowish Skin
B12 deficiency can affect the production of red blood cells, leading to a anemia, a condition called megaloblastic anemia. Anemia can manifest as pale or yellowish skin due to decreased red blood cell count and reduced oxygen-carrying capacity.
Read more about: Vitamin B12 and Red Blood Cell Formation: Why It Matters. Also, you can read this article: Anemia: Causes, Symptoms, and Management.
2- Glossitis and Mouth Ulcers
Glossitis, characterized by a swollen, red, and painful tongue, is another often overlooked symptom of B12 deficiency. The deficiency affects the normal growth and maintenance of the cells lining the tongue. Additionally, some individuals may experience recurring mouth ulcers.
You may want tp read more about: Atypical Symptoms of B12 deficiency. Scroll down to read more about vitamins!
SUMMARY
B12 deficiency is more than just fatigue and weakness, atypical symptoms discussed in this article. It can manifest in many ways within the body. Whether it’s cognitive impairment, mood disorders, balance issues, or skin changes, these lesser-known signs should not be ignored.
Also, signs like glossitis, vision changes, and muscle weakness are important. Identifying B12 deficiency early is crucial allowing for timely treatment and prevent complications. It also helps improve overall health and quality of life.
Sources
If you suspect that you may have symptoms, Helal Medical can help, offering quick, private, and convenient testing options. You may contact us here: Facebook page
Read More About Vitamins:
- Causes of Vitamin B12 Deficiency
- 5 Top Vitamin B12 Benefits, You Need to Know
- Vitamin B12 and Red Blood Cell Formation: Why It Matters
- 5 vitamins to repair your nerves
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